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Cognition enhancing derivatives of isoxazole triazoloindane GABA-A alpha 5 receptor subunit ligands
The present invention relates to compounds of formula I: 1 in which R1 is a linear group or a five membered heterocycle optionally fused to a phenyl ring, R2 is a 5-membered heterocycle, R3 is chosen from a range of substituents, m is 0-3 and n is 0 or 1; the compounds are generally inverse agonists at GABA-A receptors containing the alpha 5 subunit and so are useful in methods of enhancing cognition in subjects with diminished cognition in diseases such as Alzheimer”s Disease.
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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N3032 – PubChem