Related Products of 20744-39-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.20744-39-2, Name is Pyridazin-4-amine, molecular formula is C4H5N3. In a Article£¬once mentioned of 20744-39-2
Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton
Human sirtuin 2 (SIRT2) is an attractive target molecule for development of drugs to treat neurodegenerative diseases and cancer, because SIRT2 inhibitors have a protective effect against neurodegeneration and an anti-proliferative effect on cancer stem cells. We designed and synthesized a series of benzamide derivatives as SIRT2 inhibitor candidates. Among them, compound 17k showed the most potent SIRT2-inhibitory activity (IC50 = 0.60 muM), with more than 150-fold selectivity over SIRT1 and SIRT3 isoforms (IC50 >100 muM).
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 20744-39-2, and how the biochemistry of the body works.Related Products of 20744-39-2
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N163 – PubChem