Discovery of 35857-89-7

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Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of 6-Chloropyridazine-3-carbonitrile, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 35857-89-7

Synthesis, Pharmacological Activities and Physico-chemical Properties of 4-(Substituted amino/N4-arylpiperazinyl/aminocarbonyl)-2, 3-polymethylenequinolines

A series of N-substituted-aminoacridines (27-29) and 4-(substituted amino, N4-arylpiperazinyl and aminocarbonyl)-2,3-polymethylenequinolines (30-103) have been synthesized and tested for their CNS effects.Compounds with significant activity have been identified, which include 4-(n-butylamino)-2,3-tetramethylene quinoline (35, centbucridine) and 4-(n-heptylamino)-2,3-tetramethylenequinoline (40) as local anesthetics, 4-(n-butylamino)-2,3-pentamethylenequinoline (61) as antihistaminic and 4-(N4-phenylpiperazinyl)-2,3-pentamethylenequinoline (76) as analeptic.Witha view to determining relationship between the physico-chemical properties and biological activities of these molecules, pKa, lipophilicity and DNA binding of a few selected compounds of each type have been studied.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N902 – PubChem