Electric Literature of 5469-70-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5469-70-5, Name is 3-Aminopyridazine, molecular formula is C4H5N3. In a Article£¬once mentioned of 5469-70-5
Non-charged thiamine analogs as inhibitors of enzyme transketolase
Inhibition of the thiamine-utilizing enzyme transketolase (TK) has been linked with diminished tumor cell proliferation. Most thiamine antagonists have a permanent positive charge on the B-ring, and it has been suggested that this charge is required for diphosphorylation by thiamine pyrophosphokinase (TPPK) and binding to TK. We sought to make neutral thiazolium replacements that would be substrates for TPPK, while not necessarily needing thiamine transporters (ThTr1 and ThTr2) for cell penetration. The synthesis, SAR, and structure-based rationale for highly potent non-thiazolium TK antagonists are presented.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 5469-70-5, and how the biochemistry of the body works.Electric Literature of 5469-70-5
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N97 – PubChem