Chemistry is traditionally divided into organic and inorganic chemistry. name: 3-Phenyl-6-chloropyridazine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 20375-65-9
Rational design and binding of modified cell-wall peptides to vancomycin-group antibiotics: Factorising free energy contributions to binding
Modified cell-wall peptides have been rationally designed and studied in a semi-quantitative approach to factorising free energy contributions in binding to vancomycin-group antibiotics in aqueous solution. Binding energies for succinyl and fumaryl-D-Ala dipeptides. and N-oxalyl-gamma-aminobutyric acid analogues, are compared with binding energies for the natural substrate N-Ac-D-Ala-D-Ala, and the truncated mono-peptide N-Ac-D-Ala. We estimate the binding energy of the N-terminal carboxyl group, by four independent analyses, to he -(14 to 17)¡À7 kJ mol-1 when differences in ligand binding energies are corrected for differences in contributions from the “cost” of restricting rotations and “benefits” of hydrophobic interactions. The carboxylate interaction comprises both a charged – COO-…HN hydrogen bond plus face to face pi-stacking between the carboxylate group and an aromatic ring in the antibiotic binding pocket.
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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2649 – PubChem