One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: Methyl pyridazine-4-carboxylate, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 34231-77-1, Name is Methyl pyridazine-4-carboxylate, molecular formula is C6H6N2O2
Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications
Aroylhydrazones such as salicylaldehyde isonicotinoyl hydrazone (SIH) are tridentate iron chelators that may possess antioxidant and/or antineoplastic activities. Their main drawback, their low stability in plasma, has recently been partially overcome by exchanging the aldimine hydrogen for an unbranched alkyl group. In this study, ten analogs of methyl- and ethyl-substituted SIH derivatives with modified hydrazide scaffolds were synthesized to further explore their structure-activity relationships. Their iron-chelation efficiencies, anti- or pro-oxidant potentials, abilities to induce protection against model oxidative injury on the H9c2 cell line derived from rat embryonic cardiac tissue, cytotoxicities on the same H9c2 cells and antiproliferative activities on MCF-7 human breast adenocarcinoma and HL-60 human promyelotic leukemia cell lines were evaluated. Compounds derived from lipophilic naphthyl and biphenyl hydrazides displayed highly selective antiproliferative activities against both MCF-7 and HL-60 cell lines, and they showed markedly improved stabilities in plasma compared to SIH. Of particular interest is a hydrazone prepared from 2-hydroxypropiophenone and pyridazin-4-carbohydrazide that showed a considerable antiproliferative effect and protected cardiomyoblasts against oxidative stress with a five-fold higher selectivity compared to the parent compound SIH. Thus, this work highlighted new structure-activity relationships among antiproliferative and antioxidant aroylhydrazones and identified new lead compounds for further development.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: Methyl pyridazine-4-carboxylate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 34231-77-1, in my other articles.
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N786 – PubChem