Reference of 63910-43-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 63910-43-0, Name is 4-Chloro-5-methoxypyridazin-3(2H)-one,introducing its new discovery.
Methyl carbonium ion migration during the reaction of 4-chloro-5-methoxyl- 3(2H)-pyridazinone with trifluoroethylation agents
To synthesize 4-chloro-5-methoxy-2-(beta-trifluoroethyl)-3(2H)- pyridazinone (4), the reactions of 4-chloro-5-methoxy-3(2H)-pyridazinone (5) with RCH2CF3 (R = I, TsO, MsO, TfO) in different solvents were studied. It was found that methyl group migration took place during this reaction. An oxonium salt 9 was suggested as the active intermediate for the formation of the byproduct 4-chloro-5-methoxy-2-methyl-3(2H)-pyridazinone (7) and4-chloro-2-methyl-5-(beta-trifluoroethoxy)-3(2)-pyridazinone(8).
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 63910-43-0, and how the biochemistry of the body works.Reference of 63910-43-0
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2193 – PubChem