65202-50-8, Name is Methyl 6-chloropyridazine-3-carboxylate, belongs to pyridazine compound, is a common compound. Product Details of 65202-50-8In an article, once mentioned the new application about 65202-50-8.
Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines
In this study, we provide insight into the metabolic profile of a series of piperazin-1-ylpyridazines suffering from rapid in vitro intrinsic clearance in a metabolic stability assay using liver microsomes (e.g. compound 1 MLM/HLM t1/2 = 2/3 min). Aided by empirical metabolite identification and computational predictive models, we designed the structural modifications required to improve in vitro intrinsic clearance by more than 50-fold (e.g. compound 29 MLM/HLM t1/2 = 113/105 min).
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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2436 – PubChem