One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of 3,6-Dichloropyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2
Preparation of Heteroaryl Phenylmethanes and a 13C and 15N NMR Spectroscopic Study of their Conjugate Carbanions. Rotational Isomerism and Charge Maps of the Anions and Ranking of the Charge Demands of the Heterocycles
2-Benzylpyridazine, 4-benzylpyrimidine, 2-benzylpyrimidine and 2-benzylpyrazine, (5-8) have been prepared in order to study their 13C and 15N spectra and those of their conjugate carbanions (1-4).These systems are aza-homologues of the previously reported benzylpyridines and have been considered to evaluate the effect of aza-substitution upon rotational isomerism and charge maps in the anions.Two synthetic approaches have been followed: (i) decarboxylation of alpha-(heteroaryl)phenylacetic acids, in turn obtained by nucleophilic substitution of phenylacetonitrile anion on the pertinent halogenoazine (or a correspondingly available derivative); (ii) by nucleophilic substitution of benzyl(tributylphosphinium)ylide on the pertinent halogenoazine.The 13C and 15N NMR data for 1-4 indicate that, at room temperature, there is slow rotation about the bond between the carbanionic carbon and the carbon atom of the heterocycle: this generates geometrical isomerism in the anions 1-4.The NMR date are treated with the ?-charge-shift equations (1)-(4) to obtain the local variations of the ?-electron density.By evaluating, in anions 1-4, the fraction of ?-charge transferred to the heterocycle from the carbanionic carbon it is possible to obtain the charge demands, cx of the heterocycles, and thus rank them on the same scale as primary organic functionalities.It is found that the 4-pyrimidyl is the strongest electron-withdrawing heterocyclic residue, comparable with the acetyl group.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application In Synthesis of 3,6-Dichloropyridazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 141-30-0, in my other articles.
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1581 – PubChem