One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 13327-27-0, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 13327-27-0, Name is 6-Methylpyridazin-3(2H)-one, molecular formula is C5H6N2O
Nitrile oxide [3+2] cycloaddition: Application to the synthesis of 6-substituted 3(2H)-pyridazinones and 6-substituted 4,5-dihydro-4-hydroxy-3(2H)-pyridazinones
An efficient method for the preparation of 6-substituted 3(2H)-pyridazinones and 6-substituted 4,5-dihydro-4-hydroxy-3(2H)-pyridazinones starting from 3,5-disubstituted 4,5-dihydroisoxazoles is described. N-O bond cleavage of the isoxazoline ring promoted by molybdenum hexacarbonyl or by catalytic hydrogenation afforded the alpha-hydroxy gamma-keto esters 4a-f which were converted into 6-substituted 4,5-dihydro-4-hydroxy-3(2H)-pyridazinones 5a-f or 6-substituted 3(2H)-pyridazinones 6a-f on treatment with hydrazine hydrate at room temperature or reflux in high yield starting from 4a-f. The flexibility of this protocol has been demonstrated by the synthesis of the C-nucleoside 7 starting from the known beta-ribofuranosylnitromethane 8. Moreover, an intramolecular version of this methodology has been developed to prepare the known antiulcer tricyclic 3(2H)-pyridazinone 12.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Product Details of 13327-27-0, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 13327-27-0
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N298 – PubChem