Reference of 13327-27-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 13327-27-0, Name is 6-Methylpyridazin-3(2H)-one, molecular formula is C5H6N2O. In a Article£¬once mentioned of 13327-27-0
Pyridazinones. 3. Synthesis, Antisecretory, and Antiulcer Activities of 2-Cyanoguanidine Derivatives
3(2H)-Pyridazinone derivatives having a 2-cyanoguanidine moiety, as well as a sulfur or an oxygen atom in the alkylene side chain, were synthesized and evaluated for gastric antisecretory and antiulcer activities.The key intermediates, free amines having a thioether linkage, were synthesized by the reaction of 2-(omega-chloroalkyl)derivatives with cysteamine, while other intermediates having an ether linkage were synthesized from 2-(omega-chloroalkyl)oxymethyl derivatives.These free amines were converted via the 3-cyano-2-methyl-1-isothiourea derivatives into the desired 2-cyano-3-substituted-1-guanidine derivatives.All compounds synthesized were evaluated for gastric antisecretory activity in the pylorus-ligated rat by the method of Shay, and selected compounds were evaluated in the stress-induced ulcer test in rat.Structure-activity relationships are discussed.The molecular features for the best activities are a phenyl group in the C-6 position of the 3(2H)-pyridazinone ring, a four-atom chain length between the 3(2H)-pyridazinone ring and the 2-cyanoguanidine moiety, and a thioether rather than an ether linkage.Among them, compound 14, 2-<<<2-(2-cyano-3-methyl-1-guanidino)ethyl>thio>methyl>-6-phenyl-3(2H)-pyridazinone, had the most potent antisecretory and antiulcer activities.These compounds are neither histamine H2 receptor inhibitors nor anticholinergic agents.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 13327-27-0. In my other articles, you can also check out more blogs about 13327-27-0
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N330 – PubChem