Electric Literature of 19064-67-6, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 19064-67-6, 6-Chloro-3-hydroxypyridazine, introducing its new discovery.
Synthesis and Chemistry of Some Pyridazine Nucleosides Related to Certain 5-Substituted Pyrimidine Nucleosides
Condensation of 3,4-dichloro-6-<(trimethylsilyl)oxy>pyridazine (3) with 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose (4), by the stannic chloride catalyzed procedure, has furnished 3,4-dichloro-1-(2,3,5-tri-O-benzoyl-beta-D-ribofuranosyl)pyridazin-6-one (5).Nucleophilic displacement of the chloro groups and removal of the benzoyl blocking groups from 5 has furnished 3-chloro-4-methoxy-, 3,4-dimethoxy-, 4-amino-3-chloro-, 3-chloro-4-methylamino-, 3-chloro-4-hydroxy-, and 4-hydroxy-3-methoxy-1-beta-D-ribofuranosylpyridazin-6-one.An unusual reaction of 5 with dimethylamine is reported.Condensation of 4,5-dichloro-3-nitro-6-<(trimethylsilyl)oxy>pyridazine with 4 yielded 4,5-dichloro-3-nitro-1-(2,3,5-tri-O-benzoyl-beta-D-ribofuranosyl)pyridazin-6-one (24).Nucleophilic displacement of the aromatic nitro group from 24 is discussed.Condensation of 3 with 3,5-di-O-p-toluoyl 2-deoxy-D-erythro-pentofuranosyl chloride (28) afforded an alpha,beta mixture of 2-deoxy nucleosides.The syntheses of certain 3-substituted pyridazine 2′-deoxy nucleosides are reported.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 19064-67-6. In my other articles, you can also check out more blogs about 19064-67-6
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N755 – PubChem