One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 3-Aminopyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 5469-70-5, Name is 3-Aminopyridazine, molecular formula is C4H5N3
Design, synthesis, and evaluation of novel 4-thiazolylimidazoles as inhibitors of transforming growth factor-beta type i receptor kinase
A novel series of 4-thiazolylimidazoles was synthesized as transforming growth factor-beta (TGF-beta) type I receptor (also known as activin receptor-like kinase 5 or ALK5) inhibitors. These compounds were evaluated for their ALK5 inhibitory activity in an enzyme assay and their TGF-beta-induced Smad2/3 phosphorylation inhibitory activity in a cell-based assay. N-{[5-(1,3-benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-2-yl] methyl}butanamide 20, a potent and selective ALK5 inhibitor, exhibited good enzyme inhibitory activity (IC50 = 8.2 nM) as well as inhibitory activity against TGF-beta-induced Smad2/3 phosphorylation at a cellular level (IC50 = 32 nM).
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: 3-Aminopyridazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 5469-70-5, in my other articles.
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N58 – PubChem