Month: January 2021

14161-11-6, Name is 3,4,5-Trichloropyridazine, belongs to pyridazine compound, is a common compound. name: 3,4,5-TrichloropyridazineIn an article, once mentioned the new application about 14161-11-6.

Near-infrared (NIR) luminescent Zn(II)-Ln(III)-containing (Ln = Nd, Yb or Er) Wolf Type II metallopolymer hybrid materials

With series of hetero-binuclear Zn-Ln complexes [Zn(L)(Py) Ln(NO3)3] (H2L = N,N?-bis-(5-(3?-vinyl-phenyl)-3-methoxy-salicylidene) cyclohexane-1,2-diamine; Py = pyridine; Ln = La, 1; Ln = Nd, 2; Ln = Yb, 3; Ln = Er, 4 or Ln = Gd, 5) as the monomers, three kinds of novel PMMA, PS or PVK-supported Zn2+-Ln3+-containing Wolf Type II metallopolymer hybrid materials are obtained from the further copolymerization with MMA (methyl methacrylate), ST (styrene) or NVK (N-vinyl-carbazole), respectively. Their physical properties results in solid state show that the characteristic Ln3+-based (Ln = Nd, Yb or Er) near-infrared (NIR) luminescent emissions with relatively higher quantum ef ficiencies than those of the respective Zn-Ln-arrayed complexes in solution, are observed, besides the distinctive increase of thermal and mechanical stabilities. Especially for the Zn2+-Yb3+-containing PMMA-supported metallopolymers, the concentration self-quenching of Yb3+-based hybrid materials could be effectively prevented even at 2.5 mol%, and the replacement of PS or PVK is also helpful for energy transfer.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2530 – PubChem

 

Electric Literature of 932-22-9, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 932-22-9, 4,5-Dichloro-3(2H)-pyridazinone, introducing its new discovery.

TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS

There is provided compounds of formula (I), wherein R1, R2, X, R3 and R4 have meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 932-22-9. In my other articles, you can also check out more blogs about 932-22-9

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2266 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 5469-70-5, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 5469-70-5

NOVEL ETHYLENEDIAMINE DERIVATIVES

A compound represented by the following formula (1):Q1-Q2-To-N(R1)-Q3-N(R2)-T1-Q4 [wherein, R¹ and R² are hydrogen atoms or the like; Q¹ is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may have a substituent, or the like; Q² is a single bond or the like; Q³ represents the following group: -C(R^3a)(R^4a)-{C(R^3b)(R^4b)}m¹-{C(R^3c)(R^4c)}m²-{C(R^3d)(R^4d)}m³-{C(R^3e)(R^4e)}m⁴-C(R^3f)(R^4f)- (in which, R^3a to R^4e represent hydrogen or the like); T⁰ represents a carbonyl group or the like; and T¹ represents -COCONR- or the like]; or salt thereof, solvate thereof, or N-oxide thereof.The compound is useful as a preventive and/or therapeutic agent for cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger’s disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N34 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 20744-39-2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 20744-39-2, name is Pyridazin-4-amine. In an article£¬Which mentioned a new discovery about 20744-39-2

SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES

The present invention relates to protein-inhibitory substituted pyrrolopyridine derivatives of formula (I) in which X, Y, R1, R2, R3 and R4 are as defined herein, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, repectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients. The present invention further relates to the use, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N109 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 1121-79-5, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1121-79-5, Name is 3-Chloro-6-methylpyridazine, molecular formula is C5H5ClN2

Design of C^N=N type iridium(III) complexes towards short-wavelength emission for high efficiency organic light-emitting diodes

In this paper, by introducing the strong electron-withdrawing moiety of difluoropyridinyl to the C^NN type main-ligand, and combining a trifluoromethylated-triazole (fptz) or a picolinate (pic) as the ancillary ligand, we have synthesized two new iridium(iii) complexes with blue emission, i.e., iridium(iii) bis[3-methyl-6-(2?,4?-difluoro-pyridinato)pyridazine] trifluoromethylated-triazole (1) and iridium(iii) bis[3-methyl-6-(2?,4?-difluoro-pyridinato)pyridazine] picolinate (2). These are the first C^NN type iridium(iii) complexes with an emission wavelength shorter than 500 nm. In particular, with the increased electron withdrawing property from the ancillary ligand of fptz, the emission from 1 is more blue. Additionally, based on quantum chemistry calculations, it was found that, different from the general case of the main-ligand and Ir-atom distribution, the electrons of the highest occupied molecular orbital (HOMO) also partially locate at the ancillary ligand with very strong electron withdrawing properties. This phenomena is seldom reported in the literature. Organic light-emitting diodes with 1 or 2 as a dopant have been fabricated. High efficiencies of 41.6 cd A-1 (20.1%) with sky-blue emission and 62.8 cd A-1 (26.5%) with blue-green emission were obtained. These are the first blue electroluminescent materials based on iridium complexes with a C^NN type ligand so far.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N704 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 135034-10-5, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 135034-10-5, name is 3-Chloro-6-iodopyridazine. In an article£¬Which mentioned a new discovery about 135034-10-5

POLYMORPHIC AND HYDRATE FORMS, SALTS AND PROCESS FOR PREPARING 6-{DIFLUORO[6-(1-METHYL-1H-PYRAZOL-4-YL)[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-3-YL]METHYL}QUINOLINE

The invention relates to novel polymorphic and hydrate forms and salts of 6-{difluoro[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline, to methods for their preparation, to pharmaceutical compositions comprising at least one of said polymorphic or hydrate forms or salts, and to the therapeutic and/or prophylactic use of such compositions. The invention also provides new manners for preparing said compound.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 135034-10-5, help many people in the next few years.SDS of cas: 135034-10-5

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N3047 – PubChem

 

Reference of 20744-39-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 20744-39-2, Name is Pyridazin-4-amine, molecular formula is C4H5N3. In a Patent£¬once mentioned of 20744-39-2

BENZO[B]FURANS AS BROMODOMAIN INHIBITORS

The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 20744-39-2. In my other articles, you can also check out more blogs about 20744-39-2

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N106 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 124072-89-5, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 124072-89-5, name is Hexahydropyridazine dihydrochloride. In an article£¬Which mentioned a new discovery about 124072-89-5

HERBICIDAL PHENYLETHERS

The present invention relates to phenylethers of formula (I) or their agriculturally acceptable salts or derivatives, wherein the variables are defined according to the description, processes and intermediates for preparing the phenylethers of formula (I), compositions comprising them and their use as herbicides, i.e. for controlling harmful plants, and also a method for controlling unwanted vegetation which comprises allowing a herbicidal effective amount of at least one phenylether of formula (I) to act on plants, their seed and/or their habitat.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2170 – PubChem

 

Application of 19064-67-6, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 19064-67-6, 6-Chloro-3-hydroxypyridazine, introducing its new discovery.

STRUCTURE OF 3-CHLORO-6-HYDRAZINOPYRIDAZINE IN SOLUTIONS

It is shown by means of the fixed-structure method, UV spectroscopy and dipole-moment method that the product of the reaction of 3,6-dichloropyridazine with hydrazine in solution in methanol and acetonitrile has the 3-chloro-6-hydrazinopyridazine structure.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 19064-67-6. In my other articles, you can also check out more blogs about 19064-67-6

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N747 – PubChem

 

Electric Literature of 492431-11-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 492431-11-5, 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, introducing its new discovery.

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3

We describe the structural optimization of a lead compound 1 that exhibits dual inhibitory activities against FLT3 and CDK4. A series of pyrido[4?,3?:4,5]pyrrolo[2,3-d]pyrimidine derivatives was synthesized, and SAR analysis, using cell-based assays, led to the discovery of 28 (AMG 925), a potent and orally bioavailable dual inhibitor of CDK4 and FLT3, including many FLT3 mutants reported to date. Compound 28 inhibits the proliferation of a panel of human tumor cell lines including Colo205 (Rb +) and U937 (FLT3WT) and induced cell death in MOLM13 (FLT3ITD) and even in MOLM13 (FLT3ITD, D835Y), which exhibits resistance to a number of FLT3 inhibitors currently under clinical development. At well-tolerated doses, compound 28 leads to significant growth inhibition of MOLM13 xenografts in nude mice, and the activity correlates with inhibition of STAT5 and Rb phosphorylation.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 492431-11-5. In my other articles, you can also check out more blogs about 492431-11-5

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N3239 – PubChem