Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. COA of Formula: C6H6Cl2N2. Introducing a new discovery about 34584-69-5, Name is 3,6-Dichloro-4,5-dimethylpyridazine
Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors
We report herein the design and synthesis of a series of structural modified dimethylpyridazine compounds as novel hedgehog signaling pathway inhibitors. The bicyclic phthalazine core and 4-methylamino-piperidine moiety of Taladegib were replaced with dimethylpyridazine and different azacycle building blocks, respectively. The in vitro Gli-luciferase assay results demonstrate that the new scaffold still retained potent inhibitory potency. Piperidin-4-amine moiety was found to be the best linker between pharmacophores dimethylpyridazine and fluorine substituted benzoyl group. Furthermore, the optimization of 1-methyl-1H-pyrazol and 4-fluoro-2-(trifluoromethyl)benzamide by different aliphatic or aromatic rings were also investigated and the SAR were described. Several new derivatives were found to show potent Hh signaling inhibitory activity with nanomolar IC50 values. Among these compounds, compound 11c showed the highest inhibitory potency with an IC50 value of 2.33 nM, which was comparable to the lead compound Taladegib. In vivo efficacy of 11c in a ptch+/?p53?/? mouse medulloblastoma allograft model also indicated encouraging results.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C6H6Cl2N2, you can also check out more blogs about34584-69-5
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2478 – PubChem