Related Products of 5469-70-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.5469-70-5, Name is 3-Aminopyridazine, molecular formula is C4H5N3. In a article£¬once mentioned of 5469-70-5
Isoxazolines as potent antagonists of the integrin alpha(v)beta3
Starting with lead compound 2, we sought to increase the selectivity for alpha(v)beta3-mediated cell adhesion by examining the effects of structural changes in both the guanidine mimetic and the substituent alpha to the carboxylate. To prepare some of the desired aminoimidazoles, a novel reductive amination utilizing a trityl-protected aminoimidazole was developed. It was found that guanidine mimetics with a wide range of pK(a)’s were potent antagonists of alpha(v)beta3. In general, it appeared that an acylated 2-aminoimidazole guanidine mimetic imparted excellent selectivity for alpha(v)beta3-mediated adhesion versus alpha(IIb)beta3-mediated platelet aggregation, with selectivity of approximately 3 orders of magnitude observed for compounds 3g and 3h. It was also found in this series that the alpha- substituent was required for potent activity and that 2,6-disubstituted arylsulfonamides were optimal. In addition, the selective alpha(v)beta3 antagonist 3h was found to be a potent inhibitor of alpha(v)beta3-mediated cell migration.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 5469-70-5
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N91 – PubChem