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Synthesis and antirheumatic activity of novel tetrahydroquinoline-8-carboxylic acid derivatives

A study of the modification of N-alkylanthranilic acids to develop novel DMARDs is detailed. 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid derivatives were found to exhibit a therapeutic effect on adjuvant arthritis and a suppressive effect on bone destruction.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N935 – PubChem