Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 19064-67-6, Name is 6-Chloro-3-hydroxypyridazine, molecular formula is C4H3ClN2O, 19064-67-6, In a Article, authors is O’Malley, Daniel P.£¬once mentioned of 19064-67-6
Discovery of Pyridazinone and Pyrazolo[1,5- a]pyridine Inhibitors of C-Terminal Src Kinase
C-terminal Src kinase (CSK) functions as a negative regulator of T cell activation through inhibitory phosphorylation of LCK, so inhibitors of CSK are of interest as potential immuno-oncology agents. Screening of an internal kinase inhibitor collection identified pyridazinone lead 1, and a series of modifications led to optimized compound 13. Compound 13 showed potent activity in biochemical and cellular assays in vitro and demonstrated the ability to increase T cell proliferation induced by T cell receptor signaling. Compound 13 gave extended exposure in mice upon oral dosing and produced a functional response (decrease in LCK phosphorylation) in mouse spleens at 6 h post dose.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.19064-67-6. In my other articles, you can also check out more blogs about 19064-67-6
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N763 – PubChem