Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Formaggio, Fernando and a compound is mentioned, 20375-65-9, 3-Phenyl-6-chloropyridazine, introducing its new discovery. 20375-65-9
Linear oligopeptides. Part 329. Synthesis, characterization and solution conformational analysis of Calpha-ethyl, Calpha-benzylglycine <(alphaEt)Phe> containing peptides
For the first time a variety of derivatives and terminally blocked model peptides (to the pentapeptide level) of the sterically demanding (alphaEt)Phe residue have been synthesized (by solution methods) and fully characterized.The results of a solution conformational analysis, performed by using FTIR and 1H NMR spectroscopy, favour the conclusion that (alphaEt)Phe is a beta-turn and helix promoter as strong as (alphaMe)Phe (Calpha-methyl, Calpha-benzylglycine) but more efficient than the Phe parent amino acid.In addition, a CD study of Nalpha-para-bromobenzoylated peptides suggests that the relationship between (alphaEt)Phe chirality and the screw sense of the turn and helical structures that are formed is the same as that found for (alphaMe)Phe peptides, i.e.L-amino acids give left-handed helicities.Interestingly, this relationship is opposite to that exhibited by protein amino acids, including Phe.
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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2623 – PubChem