Month: November 2020

17973-86-3, 3,6-Dibromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 2 3-Bromo-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine As described for example 1, (5-methyl-3-phenyl-isoxazol-4-yl)-methanol (2.46 g, 13 mmol) was converted using 3,6-dibromopyridazine instead of 3,6-dichloropyridazine to the title compound (3.99 g, 89%) as a white solid. MS: m/e=348.0/346.1 [M+H]+., 17973-86-3

The synthetic route of 17973-86-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Buettelmann, Bernd; Jakob-Roetne, Roland; Knust, Henner; Thomas, Andrew; US2009/143385; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

A solution of 3,4,5-trichloropyridazine (470 mg, 2.56 mmol) in ethanol (30 ml) was cooled to 0C and saturated with ammonia gas and stirred at room temperature for 4 days. The reaction mixture was then purged with nitrogen for 2 h, and filtered to remove ammonium chloride. The filter cake was washed with anhydrous ethanol, the filtrate and washes were used directly in the next step.MS (electrospray): m/z [M+H]+ = 164, 165, 166, 167, 168, 69 4- Pyridazinamine (D11)A solution of 3,5-dichloro-4-pyridazinamine and 5,6-dichloro-4-pyridazinamine (may be prepared as described in Description 0; 419.8 mg, 2.56 mmol), sodium hydroxide (246 mg, 6.14 mmol) and Pd/C (136 mg, 0.128 mmol) in ethanol (20 ml) was hydrogenated overnight. The reaction mixture was purged with nitrogen and filtered. The filtrate was concentrated to a residue and triturated with ethyl acetate. The mixture was filtered again to collect a solid which was dried to yield the title compound as a yellow solid. 98 mg.MS (electrospray): m/z [M+H]+ = 96

14161-11-6, As the paragraph descriping shows that 14161-11-6 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; NICHOLS, Paula Louise; EATHERTON, Andrew John; BAMBOROUGH, Paul; JANDU, Karamjit Singh; PHILPS, Oliver James; ANDREOTTI, Daniele; WO2011/38572; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66346-87-0,6-Chloro-5-methylpyridazin-3-amine,as a common compound, the synthetic route is as follows.

The reaction is performed underan argon-atmosphere. 6-Chloro-5-methylpyridazin-3-amine (3.00 g; 20.90 mmol), ie/f-butyl 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 ,2,3,6- tetrahydropyridine-1 -carboxylate (7.1 1 g; 22.98 mmol) and sodium carbonate (2 mol/L, aq. solution; 41 .79 mL; 83.58 mmol) in 1 ,4-dioxane (150 mL) is purged with argon. After 5 minutes Xphos 2nd Gen. (0.49 g; 0.63 mmol) is added and the mixture is stirred over night in a sealed vial at 100C. The reaction mixture is concentrated under reduced pressure. The residue is taken up in water and extracted several times with EtOAc. The combined organic layers are washed with brine, dried over Na2S04, filtered and concentrated under reduced pressure. The residue is purified by silica gel chromatography (DCM/MeOH). (1086) Yield: 5.20 g (86%) ESI-MS: m/z = 291 [M+H]+ Rt(HPLC): 0.79 min (method 10), 66346-87-0

The synthetic route of 66346-87-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HYDRA BIOSCIENCES, INC.; BOUYSSOU, Thierry; GOTTSCHLING, Dirk; HEINE, Niklas; SMITH KEENAN, Lana Louise; LOWE, Michael D.; RAZAVI, Hossein; SARKO, Christopher Ronald; SURPRENANT, Simon; TAKAHASHI, Hidenori; TURNER, Michael Robert; WU, Xinyuan; (182 pag.)WO2019/81637; (2019); A1;,
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Pyridazine | C4H4N2 – PubChem

1632-76-4, 3-Methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: 6-methylpyridazine-3-carbonitrile (2)To a stirring solution of 3-methylpyridazine (1.1 g, 11.80 mmol) in dichloromethane (20 mL) was added AICI3(0.05 g) followed by trimethylsilylcyanide (2.1 g, 21.1 mmol). After 20 min, a solution of p-toluenesulfonyl chloride (3.8 g, 20.1 mmol) in dichloromethane (5 mL) was added slowly and the solution was stirred for 16 h. The solvent was removed in vacuo and ethanol (10 ml) was added and stirred for 15 min, then filtered to give a white solid. The solid was dissolved in THF (200 mL) and DBU (1.6 mL, 10.5 mmol) was added. After 1 h, the solvent was removed in vacuo and the residue was partitioned between hexane and saturated aqueous NH4C1. The aqueous phase was basified with solid a2C03, and then extracted with EtOAc (100ml*2). The combined ethyl acetate phases was dried over MgS04, filtered and concentrated to give compound 2 as a white solid.

1632-76-4, The synthetic route of 1632-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; MCCOMAS, Casey, C.; REGER, Thoma, S.; QI, Changhe; WO2014/150114; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.372118-01-9,Methyl 4,6-dichloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.

Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (109 mg, 0.53 mmol),3-fluoro-4- (tetrahydro-2H-pyran-4-yl) aniline 95c (103mg, 0.53mmol),Diisopropylethylamine (682 mg, 5.28 mmol) and acetonitrile (4 mL) were mixed, heated to 90 C and stirred for 18 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 100/0 to 3/7),The target product 6-chloro-4-((3-fluoro-4- (tetrahydro-2H-pyran-4-yl) phenyl) amino) pyridazine-3-carboxylic acid methyl ester 95d (67 mg, orange oily ), Yield: 34%.

372118-01-9, 372118-01-9 Methyl 4,6-dichloropyridazine-3-carboxylate 17848322, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1837-55-4, 3,5-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[01040] Sodium methoxide (5.84 g, 0.108 mol) was added to a stirred solution of 3,5-dichloropyridazine (8 g, 0.054 mol) in 350 mL of THF at 0C. After the addition, the mixture was stirred at room temperature for 16 h. The mixture was quenched with water (100 mL), extracted with EA (300 mL X 2). The combined organic solvents were dried over anhydrous Na2S04, concentrated and purified by silica gel chromatography (0-40% EtO Ac/petroleum ether) which gave 1.5 g of 5-chloro-3-methoxypyridazine as yellow solid (17% yield). LCMS: m/z 145.1 [M+H]+; = 1.42 min., 1837-55-4

As the paragraph descriping shows that 1837-55-4 is playing an increasingly important role.

Reference£º
Patent; SKYHAWK THERAPEUTICS, INC.; LUZZIO, Michael; MCCARTHY, Kathleen; HANEY, William; (470 pag.)WO2019/28440; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 4.Preparation of 6-chloro-4-methoxy-pyridazine-3-carboxylic acid methyl ester 6 sodium methoxide (25 wt % I methanol, 1.1 ML) is added to a stirred solution of 4,6-dichloro-pyridazine-3-carboxylic acid methyl ester (1.03 g, 5 mmol) in THF (25 ML) cooled to 0 C. The reaction mixture is stirred at room temperature overnight and then poured into 1N HCl (8 ML).The resulting solution is then neutralized by saturated NaHCO3. EtOAc (20 ML) is added and the layers are separated.The aqueous layer is extracted twice with EtOAc (20 ML) and the combined extracts are washed with brine (25 ML), dried (Na2SO4) and evaporated.The residue is then purified by flash column chromatography (silica gel, eluted with 2:1 hexane:EtOAc) to give 6-chloro-4-methoxy-pyridazine-3-carboxylic acid methyl ester as a white solid., 372118-01-9

As the paragraph descriping shows that 372118-01-9 is playing an increasingly important role.

Reference£º
Patent; Xie, Linghong; Han, Bingsong; Xu, Yuelian; Maynard, George D.; US2004/77653; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50901-46-7,1-(Pyridazin-4-yl)ethanone,as a common compound, the synthetic route is as follows.

To a solution of 1-pyridazin-4-ylethanone (0.3 g) in 1 ,4-dioxane (1.5 ml_) was added (0920) tert- butyl /V-aminocarbamate (0.327 g) and the reaction heated at 70C for 90 minutes. The reaction mixture was concentrated to give tert- butyl A/-[(E)-1-pyridazin-4-ylethylideneamino]carbamate which was used without further purification. (0921) NMR (400 MHz, CDCIs) 9.59 (dd, 1 H), 9.19 (dd, 1 H), 8.00 (s, 1 H), 7.77 (dd, 1 H), 2.21 (s, 3H), 1.57 (s, 9H), 50901-46-7

As the paragraph descriping shows that 50901-46-7 is playing an increasingly important role.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; SCUTT, James, Nicholas; WILLETTS, Nigel, James; SONAWANE, Ravindra; PHADTE, Mangala; KANDUKURI, Sandeep, Reddy; SASMAL, Swarnendu; ARMSTRONG, Sarah; MCGRANAGHAN, Andrea; (155 pag.)WO2019/185875; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20698-04-8,3,6-Diiodopyridazine,as a common compound, the synthetic route is as follows.

Example 29 A mixture of 5.2 parts of 3,6-diiodopyridazine, 3.5 parts of 1-[3-(trifluoromethyl)phenyl]piperazine, 3.2 parts of sodium carbonate and 90 parts of N , N -dimethylacetamide was stirred and heated overnight at 70C. The reaction mixture was poured onto water. The precipitated product was filtered off and crystallized from 2-propanol, yielding 3.2 parts (48%) of 3-iodo-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-pyridazine; mp. 144.6C (compound 202)., 20698-04-8

20698-04-8 3,6-Diiodopyridazine 250383, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; EP156433; (1991); B1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.93319-65-4,Pyridazin-3-ylmethanamine,as a common compound, the synthetic route is as follows.

93319-65-4, General procedure: A solution of 1-isopropyl-6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid (preparation 3, 65 mg, 0.192 mmol), TBTU (75 mg, 0.232 mmol), N-methylmorpholine (42 muL, 0.383 mmol) in DMF (1 mL) is stirred for 15 min at room temperature. C-(5-Methyl-[1,3,4]oxadiazol-2-yl)-methylamine (24 mg, 0.211 mmol) is added and the reaction mixture is stirred for 18 h at room temperature. The reaction mixture is purified by preparative reversed-phase HPLC (Sunfire, gradient of acetonitrile in water, 0.1% TFA, 60 C.). The following examples are prepared as described for Example 3.1, substituting preparation 3 with preparation 4, substituting N-methylmorpholine with triethylamine and employing the appropriate amines, respectively.

93319-65-4 Pyridazin-3-ylmethanamine 22639518, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; OOST, Thorsten; FIEGEN, Dennis; GNAMM, Christian; HANDSCHUH, Sandra; PETERS, Stefan; ROTH, Gerald Juergen; US2014/57920; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem