Month: November 2020

5096-73-1, 6-Chloropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5096-73-1, General procedure: 6-Chloropyridazine-3-carboxylic acid (1 equivalent) was dissolved in DCM (10ml). To this solution catalytic amount of DMF and oxalyl choloride (1.1 equivalent) were added and the reaction mixture was stirred at room temperature for 2h. After 2h, reaction mixture cooled at ice bath then, TEA (3 equivalent) and appropriate 2-substituted ethan-1-amine derivative (1.1 equivalent) were added and stirred for additional 1h at room temperature. At the end of this period, reaction mixture was evaporated to dryness then the precipitate boiled with water and petroleum ether respectively. The resulting precipitate was filtered to yield intermediates (1-4), which were used for method A without further purification.

The synthetic route of 5096-73-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kilic, Burcu; Gulcan, Hayrettin O.; Aksakal, Fatma; Ercetin, Tugba; Oruklu, Nihan; Umit Bagriacik; Dogruer, Deniz S.; Bioorganic Chemistry; vol. 79; (2018); p. 235 – 249;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture 10.0 g (67.1 mmol) of 3,6-dichloropyridazine and 40 ml of hydroiodic acid (57% in water) is stirred for 24 hours at 700C. After cooling down the reaction mixture is poured on ice, neutralized with 120 ml of potassium hydroxide solution (20% in water) and filtered. The residue is washed with 1000 ml of water, 50 ml of sodium thiosulfate solution (10 % in water) and 10 ml of n-hexane. The residue is recrystallised from EtOAc.Yield: 9.4 g (42% of theory),

141-30-0, The synthetic route of 141-30-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/71646; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

65202-50-8, Methyl 6-chloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

65202-50-8, A solution of Example 65D (600mg, 3.48mmol), vinyl pinacol borate (803.2mg, 5.22mmol), potassium carbonate(961.07mg, 6.95mmol) and Pd(PPh3)4 (602.66mg, 521.53mmol) in DMF (8mL) was stirred at 100¡ãC for 5 hours undernitrogen atmosphere. The solution was cooled, filtered and concentrated in vacuo. The residue was purified by columnchromatography to give the title compound (500mg, yield 84.02percent). 1H NMR (400MHz, CHLOROFORM-d) ppm 8.18 (d,J=8.8 Hz, 1H), 7.72 (d, J=8.8 Hz, 1H), 7.16 (dd, J=11.0, 17.8 Hz, 1H), 6.44 (d, J=17.8 Hz, 1H), 5.85 (d, J=10.8 Hz, 1H),4.10 (s, 3H).

The synthetic route of 65202-50-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Harbin Zhenbao Pharmaceutical Co., Ltd.; Medshine Discovery Inc.; CHEN, Shuhui; CHEN, Zhengxia; DAI, Meibi; XIE, Cheng; LI, Peng; ZHANG, Yang; LIANG, Guibai; WANG, Qiang; LIAO, Jiangpeng; SUN, Fei; HU, Guoping; LI, Jian; (166 pag.)EP3333157; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5788-58-9, 4,5-Dibromopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5788-58-9, EXAMPLE 6 4-Bromo-5-(3-n-pentyloxy-4-methoxybenzylamino)-3(2H)-pyridazinone (Compound No. 39) STR26 A mixture comprising 1.52 g of 4,5-dibromo-3(2H) pyridazinone, 4.01 g of 3-n-pentyloxy-4-methoxybenzylamine and 60 ml of ethanol was refluxed under stirring for 7.5 hours. Then, ethanol was distilled off under reduced pressure, and the residue thus obtained was extracted with ethyl acetate. The extract was sequentially washed with dilute hydrochloric acid and water, and dried over sodium sulfate. Then, the solvent was distilled off, and the residue thus obtained was crystallized from ethyl acetate-diethyl ether to obtain 1.42 g of the above identified compound as pale yellow crystals having a melting point of from 148 to 150 C. NMR(CDCl3)delta: 7.51 (1H, s), 6.82 (3H, s), 5.28 (1H, brs), 4.51, 4.41 (total 2H, each s), 3.97 (2H, t), 3.84 (3H, s), 2.05-1.05 (6H, m), 0.96 (3H, t) Mass (m/e): 395 (M+), 316 (100%), 207, 137

The synthetic route of 5788-58-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nissan Chemical Industries Ltd.; US4892947; (1990); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

2166-31-6, 6-Phenylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

135 ml (135 mmole) of a solution of phenylmagnesium bromide (IM) in THF was added to a hot suspension of 6-phenylpyridazinone compound 7.8g (45 mmole) in dry toluene (50 ml). The mixture was-refluxed for 8h, left overnight at ambient temperature, then decomposed with a saturated solution of ammonium chloride. The organic layer was separated, and the aqueous layer was extracted with 100ml of ethyl acetate. The solvent was removed and the residue was crystallized from ethanol. The crystals were collected by filtering and dried over a medium frit sintered glass funnel in vacuo to give 5.6 g of white crystals. Yield was 50%, confirmed by ESI-MS. ESI-MS: m/z 250.1 (M+H+)., 2166-31-6

The synthetic route of 2166-31-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NORTHWESTERN UNIVERSITY; WO2007/127475; (2007); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5096-73-1, 6-Chloropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of -chloropyridazine-S-carboxylic acid (60mg, 0 38mmol) in THF (1OmL) was added EDCI (107mg, 0 46mmol), followed HOBt (69mg, 0.46mmol), and the reaction was stirred at r.t. for 15 min. 4-[(^)-l-(N-Hydroxycarbamimidoyl)ethoxy]piperidine-l- carboxylic acid isopropyl ester (Preparation 12, 103mg, 0 38mmol) was added and stirring continued for 4 h, before removing the solvent in vacuo The resulting residue was partitioned between EtOAc and water, then the organic phase was separated, washed with sat NaHCO3 solution, dried (MgSO4) and the solvent removed in vacuo. The residue was dissolved in toluene and heated to reflux for 16 h before concentrating the solvent in vacuo and redissolving the product in EtOAc. The solution was washed with water, then brine, and dried (MgSOzO, before removal of the solvent in vacuo Purification by column chromatography (IH:EtOAc, 1 1) afforded the title compound: RT = 3.87 min, m/z (ES+) = 495.2 [M + H]+, 5096-73-1

As the paragraph descriping shows that 5096-73-1 is playing an increasingly important role.

Reference£º
Patent; PROSIDION LIMITED; BARBA, Oscar; DAVIS, Susan, Helen; FYFE, Matthew, Colin, Thor; JEEVARATNAM, Revathy, Perpetua; SCHOFIELD, Karen, Lesley; STAROSKE, Thomas; STEWART, Alan, John, William; SWAIN, Simon, Andrew; WITHALL, David, Matthew; WO2010/103335; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

14161-11-6, 3,4,5-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3,4,5-trichloropyridazine (0.25 g, 1.363 mmol), 4-(2,3- dichlorophenyl)piperidine, 4-methylbenzenesulfonate salt (0.547 g, 1.3 63 mmol), andpotassium carbonate (0.396 g, 2.86 mmol) in dioxane (5 ml) was heated to reflux for1 h. The mixture was cooled and 35% hydrazine in water (2.469 ml, 27.3 mmol) was added. The mixture was heated to reflux for 16 h. The reaction was diluted with ethyl acetate and water. The ethyl acetate layer was washed with water, dried over magnesium sulfate, and concentrated to give 4-chloro-5-(4-(2,3-dichlorophenyl)piperidin- 1 -yl)-3 -hydrazinylpyridazine as a brown oil. (M+H) =374.1.

14161-11-6, The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

932-22-9, 4,5-Dichloro-3(2H)-pyridazinone is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solutionof 4,5-dichloropyridazin-3(2H)-one (1, 3.0 mmol) andEt3N (3.6 mmol) in CH2Cl2 (30 mL) was added dropwise theappropriate alkyl/aryl chloroformate (2, 3.9 mmol) and themixture was stirred for 10 min at 5 C (Scheme 1). Thereaction mixture was washed using water (5 ¡Á 50 mL). Theorganic layer was dried over anhydrous magnesium sulfate,and then evaporated under reduced pressure. The resultingresidue was recrystallized from THF/n-hexane (1:3, v/v) togive the product 3., 932-22-9

The synthetic route of 932-22-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sung, Gi Hyeon; Bo, Ram Kim; Ryu, Ki Eun; Kim, Jeum-Jong; Yoon, Yong-Jin; Bulletin of the Korean Chemical Society; vol. 35; 9; (2014); p. 2758 – 2764;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17973-86-3,3,6-Dibromopyridazine,as a common compound, the synthetic route is as follows.

A suspension of 3,6-dibromopyridazine and 4-hydroxypiperidine (1.5 equiv.) in isopropanol (2 M) was heated in microwave at 150 0C. After a period of 20 min., the crude residue was partitioned between ethyl acetate and water. The organic phase was separated, dried over MgSO4, filtered and evaporated under reduced pressure. The title compound was purified by flash chromatography eluting with 50% acetone in dichloromethane, 17973-86-3

The synthetic route of 17973-86-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2008/46226; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

84956-71-8,84956-71-8, 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of the substituted pyridazinone and either a benzylic alcohol or benzylic bromide in dimethylformamide was treated with cesium carbonate then optionally heated to 55-80 C. After cooling to ambient temperature, the crude product was isolated as a solution in ethyl acetate, washed with water and aqueous sodium chloride then dried, filtered and concentrated. Subsequent purification by chromatography on silica afforded the title compound.

84956-71-8 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one 2782225, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Lantheus Medical Imaging, Inc.; Cesati, Richard R.; Radeke, Heike S.; Pandey, Suresh K.; Purohit, Ajay; Robinson, Simon P.; US2015/196672; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem