Month: November 2020

65202-50-8, Methyl 6-chloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,65202-50-8

To a suspension of methyl 6- chloropyridazine-3-carboxylate (1 g, 5.8 mmol) and imidazole (400 mg, 5.8 mmol) in dry DMF (10 mL), was added K2CO3 (950 mg, 6.8 mmol) and the reaction mixture was stirred at 120 C for 3h. The reaction was monitored by LCMS. After complete conversion to methyl 6- (1 H-imidazol-1-yl)pyridazine-3-carboxylate, 2.5 M aq. LiOH (2.8 mL, 6.96 mmol) was added to the reaction mixture and stirred at 60 C for 1 h. The reaction was monitored by LCMS. After completion of the reaction, the reaction mixture was acidified with aq.1 M HCI and the resulting precipitate was filtered and washed with water, to obtain the acid A (720 mg) as an off-white solid which was used in the next step without further purification. LC-MS (ESI+): m/z 191.0 [M+H]+.

As the paragraph descriping shows that 65202-50-8 is playing an increasingly important role.

Reference£º
Patent; THE SCRIPPS RESEARCH INSTITUTE; LAIRSON, Luke, L.; CHIN, Emily, N.; CHATTERJEE, Arnab; KUMAR, Manoj; ALBERO, Ana, Maria, Gamo; PETRASSI, Mike; SCHULTZ, Peter; YU, Chenguang; TAMIYA, Junko; VERNIER, William; GUPTA, Anil; MODUKURI, Ramkumar; (0 pag.)WO2019/165032; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1632-76-4,3-Methylpyridazine,as a common compound, the synthetic route is as follows.

1632-76-4, General procedure: K2[M'(CN)4].H2O was prepared by mixing the stoichiometric amounts of nickel(II) chloride hexahydrate (1 mmol, 0.238 g) or palladium(II) chloride (1 mmol, 0.177 g) or platinum(II) chloride(1 mmol, 0.266 g) in water (10 mL) solutions with potassiumcyanide (4 mmol, 0.260 g) in water (10 mL) solutions. These solutions were filtered and allowed to evaporate at room temperature in order to crystallize. The K2[M'(CN)4]H2O (1 mmol) complexes(M’ , 0.259 g for Ni(II), 0.306 g for Pd(II), 0.395 g for Pt(II)) were dissolved in water (50 mL). To these solutions, 1 mmol of zinc(II) chloride or 1 mmol of cadmium(II) chloride hemi(pentahydrate)dissolved in water (10 mL) were added with continuous stirring approximately for 4h at 50¡ãC in a temperature-controlled bath.The M[M'(CN)4]H2O compounds obtained were filtered and dried in air. The complexes were prepared by mixing together with the50 mL of water solution of 1 mmol of Zn[Ni(CN)4]H2O = 0.246 g,Zn[Pd(CN)4]H2O = 0.293 g or Zn[Pt(CN)4]H2O = 0.382 g, separately.To M[M'(CN)4]H2O solutions, 3-mpdz (2 mmol, 0.188 g) dissolved in ethanol (10 mL) was added with continuous stirring and after afew minutes ammonia (5 mL, 28percent) was added a few drops to resulting solution with continuous stirring approximately for 5h at 60¡ãCin a temperature-controlled bath and then filtered. The resulting clear solutions were kept for crystallization at room temperature. In the meantime, the ammonia was moved away from the solutions itself. Within about a week bright crystals were obtained. The procedure for the syntheses of cadmium complexes was similar to that used for zinc complexes, except that the Zn[M'(CN)4]H2Owas used instead of Cd[M'(CN)4]H2O [Cd[Ni(CN)4]H2O = 0.246 g,Cd[Pd(CN)4]H2O = 0.340 g or Cd[Pt(CN)4]H2O = 0.429 g]. The C, H,N analyses were carried out for the complexes and were found tofit the proposed formulae well.

The synthetic route of 1632-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Goer, Kansu; Kuerkcueo?lu, Guene? Sueheyla; Ye?ilel, Okan Zafer; Bueyuekguengoer, Orhan; Inorganica Chimica Acta; vol. 414; (2014); p. 15 – 20;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.

Step 1: 6-Chloropyridazine-3-carboxylic acidTo concentrated sulfuric acid (175 mL) in a flask equipped with a mechanical stirrer was added 3-chloro-6-methylpyridazine (25 g, 194 mmol). To the resulting solution was added K2Cr2O7 (69 g, 234 mmol) portionwise over 40 min, using a cold water bath to maintain the internal temperature below 65 0C. The reaction was then maintained at 60 0C for 3 h. The mixture was cooled and quenched by the addition of ice, then poured onto 200 g ice and extracted eight times with EtOAc. The combined organic layers were washed with brine, dried over MgSO4 and evaporated to give the title compound., 1121-79-5

As the paragraph descriping shows that 1121-79-5 is playing an increasingly important role.

Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/71023; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5469-70-5,3-Aminopyridazine,as a common compound, the synthetic route is as follows.

A RBF was charged with (P)-perfluorophenyl 2-oxo-1-(2,3′,4′-trifluoro-5-methoxy-[1,1′-biphenyl]-4-yl)-1,2-dihydroquinoline-6-sulfonate (151.1 mg, 0.241 mmol) and pyridazin-3-amine (34.4 mg, 0.361 mmol). DMSO (602 mul) was added to give a solution which was then diluted with THF (1806 mul). The flask was cooled in an ice-water bath for 10 min, then lithium bis(trimethylsilyl)amide (1M in THF) (530 mul, 0.530 mmol) was added dropwise. After 15 min total, the mixture was diluted with 1N aq. HCl and EtOAc. The layers were separated, and the aq. layer was extracted with EtOAc (1*). The combined organic extracts were dried over sodium sulfate, filtered, and concentrated. The residue was taken up in MeOH and filtered through a 0.2 micron filter. The resulting solution was purified by reverse-phase HPLC (25-70% CH3CN/H2O with 0.1% TFA). Fractions containing the desired product were combined and lyophilized to give (P)-2-oxo-N-3-pyridazinyl-1-(2,3′,4′-trifluoro-5-methoxy-4-biphenylyl)-1,2-dihydro-6-quinolinesulfonamide (55 mg, 0.102 mmol, 42.4% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) delta=14.5 (br. s, 1H), 8.52-8.06 (m, 3H), 8.01-7.76 (m, 3H), 7.76-7.30 (m, 5H), 6.91-6.62 (m, 2H), 3.73 (br. s., 3H). m/z (ESI) 539.0 (M+H)+., 5469-70-5

As the paragraph descriping shows that 5469-70-5 is playing an increasingly important role.

Reference£º
Patent; Amgen Inc.; Weiss, Matthew; Boezio, Alessandro; Boezio, Christiane; Butler, John R.; Chu-Moyer, Margaret Yuhua; Dimauro, Erin F.; Dineen, Thomas; Graceffa, Russell; Guzman-Perez, Angel; Huang, Hongbing; Kreiman, Charles; La, Daniel; Marx, Isaac E.; Milgrim, Benjamin Charles; Nguyen, Hanh Nho; Peterson, Emily; Romero, Karina; Sparling, Brian; US9212182; (2015); B2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

504-30-3, Pyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 40A tert-butyl 4-(6-oxo-1(6H)-pyridazinyl)-1-piperidinecarboxylate tert-Butyl 4-bromo-1-piperidinecarboxylate (1.00 g, 3.78 mmol) in DMF (20 mL) was treated with K2CO3 (523 mg, 3.78 mmol) and 3(2H)-pyridazinone (340 mg, 3.78 mmol) and then heated at 45 C. for 60 hours. The reaction mixture was allowed to cool to room temperature, poured into water (80 mL) and extracted with ethyl acetate (80 mL). The organic layer was washed with brine (3*50 mL), dried over MgSO4, filtered, and the filtrate concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (elution with hexanes:ethyl acetate, 3:1) to provide the title compound (180 mg, 17% yield). 1H NMR (300 MHz, DMSO-d6) delta1.41 (s, 9H), 1.66 (m, 4H), 2.91 (m, 2H), 4.05 (m, 2H), 4.96 (m, 1H), 6.93 (dd, 1H, J=1.5, 9.0 Hz), 7.39 (dd, 1H, J=3.0, 9.0 Hz), 7.95 (dd, 1H, J=3.0, 9.0 Hz); (MS (DCI/NH3) m/e 280 (M+H)+., 504-30-3

As the paragraph descriping shows that 504-30-3 is playing an increasingly important role.

Reference£º
Patent; Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q.; US2004/29887; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

89466-38-6,89466-38-6, 6-Chloro-3-methoxy-4-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of tert-butyl 4-((6-methoxy-5-methylpyridazin-3- yl)oxy)piperidine- 1 -carboxylate. To a solution of tert-butyl 4-hydroxy-4-methylpiperidine-l- carboxylate (761 mg, 3.78 mmol) in DMF (7.9 mL) was added sodium hydride (60% w/w, 164 mg, 4.10 mmol). The reaction was stirred for 5 min at ambient temperature. Then 6-chloro-3- methoxy-4-methylpyridazine (500 mg, 3.15 mmol) was added and reaction stirred overnight at 95C. The reaction was cooled to ambient temperature and diluted with water and extracted with EtOAc. Combined organics were washed with saturated NaHC03(aq), water, and brine. The combined organic extracts were dried over anhydrous Na2S04(S), filtered and concentrated in vacuo to afford the title compound (assumed quantative yield, 1.019 g) in sufficient purity for step 2. MS (apci) m/z = 324.1 (M+H).

As the paragraph descriping shows that 89466-38-6 is playing an increasingly important role.

Reference£º
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COLLIER, James; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; RAMANN, Ginelle A.; TANG, Tony P.; REN, Li; WALLS, Shane M.; (946 pag.)WO2018/71454; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.492431-11-5,1-Boc-4-(6-Chloropyridazin-3-yl)piperazine,as a common compound, the synthetic route is as follows.

A mixture of tert-butyl 4- (6-chloropyridazin-3-yl)piperazine-l-carboxylate (0.060 g, 0.20 mmol), compound 83 (0.054 g, 0.20 mmol), Xantphos (0.017 g, 0.030 mmol), Pd2(dba)3 (0.014 g, 0.015 mmol), and sodium tert-butoxide (0.029 g, 0.30 mmol) in dioxane was purged with nitrogen gas for 1 minute. The reaction was heated at 12O0C for 6 hours and then cooled to room temperature. The solvent was removed by filtration. The residue was washed with 2 x ImI dioxane. The product was then dissolved in 1OmL methanol/DCM (1 :1) and concentrated. The crude material was re-dissolved in 4mL methanol and purified on a C-18 reversephase column (150 x 30 mm, 4 micro) using Mass directed preperative HPLC and gradient elution of acetonitrile in water containing 0.1%TFA to give the title compound 162. LCMS-ESI (POS), M/Z, M+l: 532.3

492431-11-5, 492431-11-5 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine 21925370, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; AMGEN INC.; WO2009/85185; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20698-04-8,3,6-Diiodopyridazine,as a common compound, the synthetic route is as follows.

0.50 mL (6.6 mmol) isopropanol are added to 289 mg (7.23 mmol) sodium hydride (60%) in 100 mL THF and the mixture is stirred for 30 min at rt. After that time, 2.0 g (6.0 mmol) 3,6-diiodo-pyridazine are added and the mixture is stirred for 14 h at rt and for 14 h at 50C. After that time, the mixture is poured into water and extracted with EtOAc. The organic layer is washed with water (2x) and dried over sodium sulphate. The solvent is removed in vacuo and the residue is purified by column chromatography (silicia gel; heptane: EtOAc gradient 0 to 50%).C7H9IN2O (M= 264.06 g/mol)ESI-MS: 265 [M+H]+ Rt (HPLC): 3.14 min (method P), 20698-04-8

20698-04-8 3,6-Diiodopyridazine 250383, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ROTH, Gerald Juergen; FLECK, Martin; NEUBAUER, Heike; NOSSE, Bernd; WO2012/32014; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

63001-30-9, Methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

B. A mixture of 6-hydroxypyridazine-3-carboxylic acid methyl ester obtained above and phosphorous oxychloride were carefully heated to reflux temperature and maintained there for 2.5 h. The reaction mixture was then cooled and evaporated in vacuo to remove excess phosphorylchloride, and the residue was then poured into ice water. The precipitate was collected by filtration, washed with saturated NaHCO3 and water, and dried under vacuum to yield the product as a yellow solid (4.359 g, 79percent yield)., 63001-30-9

63001-30-9 Methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate 9124994, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Xenon Pharmaceuticals Inc.; Abreo, Melwyn; Chafev, Mikhail; Chakka, Nagasree; Chowdhury, Sultan; Fu, Jian-Min; Gschwend, Heinz, W.; Holladay, Mark, W.; Hou, Duanjie; Kamboj, Rajender; Kodumuru, Vishnumurthy; Li, Wenbao; Liu, Shifeng; Raina, Vandna; Sun, Sengen; Sun, Shaoyi; Sviridov, Serguei; Tu, Chi; Winther, Michael, D.; Zhang, Zaihui; (94 pag.)EP2316827; (2016); B1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1632-76-4, 3-Methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a 3-Chloromethylpyridazine Trichloroisocyanuric acid (1.04 g, 4.46 mmol) was added to a boiling solution of 3-methylpyridazine (1.00 g, 10.6 mmol) in chloroform (30 ml) under nitrogen and the mixture heated at reflux overnight. The mixture was cooled to room temperature, diluted with dichloromethane and filtered through a pad of celite. The filtrate was washed with 1N sodium hydroxide solution (2*100 ml) and brine (*2), dried (MgSO4) and evaporated in vacuo to give 3-chloromethylpyridazine., 1632-76-4

As the paragraph descriping shows that 1632-76-4 is playing an increasingly important role.

Reference£º
Patent; Merck Sharp & Dohme Limited; US6200975; (2001); B1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem