In an article, published in an article,authors is Bender, Aaron M., once mentioned the application of 141-30-0, Name is 3,6-Dichloropyridazine,molecular formula is C4H2Cl2N2, is a conventional compound. this article was the specific content is as follows. 141-30-0
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists
This letter describes the synthesis and structure activity relationship (SAR) studies of structurally novel M4 antagonists, based on a 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazine core, identified from a high-throughput screening campaign. A multi-dimensional optimization effort enhanced potency at human M4 (hM4 IC50s?141-30-0
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1615 – PubChem