In an article, published in an article,authors is Betti, Laura, once mentioned the application of 932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone,molecular formula is C4H2Cl2N2O, is a conventional compound. this article was the specific content is as follows. 932-22-9
alpha1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus.
Our previous work on pyridazinone-arylpiperazine derivatives suggested some structural features that a compound should have to show high affinity and good selectivity for alpha(1) adrenoceptors (AR) with respect to alpha(2)-AR. Accordingly, two classes of new alkoxyphenylpiperazinylheptylpyridazinones were designed and synthesized to evaluate the effect of the alkoxy substituent on affinity and selectivity. As expected, affinity increased with larger alkoxy groups. Affinity values are all comparable with that of the reference compound (prazosin), with the exception of compound 1c found 4.5-fold more active than prazosin.
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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2295 – PubChem