In an article, published in an article,authors is Beller, Matthias, once mentioned the application of 1121-79-5, Name is 3-Chloro-6-methylpyridazine,molecular formula is C5H5ClN2, is a conventional compound. this article was the specific content is as follows. 1121-79-5
Efficient Palladium-Catalyzed Alkoxycarbonylation of N-Heteroaryl Chlorides – A Practical Synthesis of Building Blocks for Pharmaceuticals and Herbicides
The alkoxycarbonylation of various N-heteroaryl chlorides was examined in detail. Studies of the butoxycarbonylation of 2- and 3-chloropyridine revealed the importance of selecting both the right phosphine ligand and ligand concentration in order to obtain efficient conversion and selectivity. Amongst the different ligands tested, 1,4-bis(diphenylphosphino)butane (dppb) and 1,1′-bis(diphenylphosphino)ferrocene (dppf) led to the most efficient palladium catalyst systems for the conversion of 2- and 4-chloropyridines and similar heteroaryl chlorides. The best catalytic systems for the alkoxycarbonylation of less activated substrates, such as 3-chloropyridines, were found to be those containing 1,4-bis(dicyclohexylphosphino)butane. Good to excellent yields of a number of N-heterocyclic carboxylic acid esters were realized by applying the appropriate ligand in the right concentration at low catalyst loadings (0.005-0.5 mol percent Pd). For the first time catalyst turnover numbers (TON) of up to 13,000 were obtained for the carbonylation of a (hetero)aryl chloride.
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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N651 – PubChem