19064-67-6, 6-Chloro-3-hydroxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound 2 (1.5 g, 12 mmol) was dissolved in water.Add liquid bromine (1.8 mL, 36 mmol),Potassium bromide (4.3 g, 36 mmol),After potassium acetate (1.76 g, 18 mmol),Heated to reflux,TLC was used to detect the progress of the reaction.The reaction was stirred overnight.The reaction is complete,Add appropriate amount of ethyl acetate and dilute the extract.Washed with saturated saline,The organic phase is concentrated,Separation and purification by silica gel column chromatography (ethyl acetate / petroleum ether = 1/2).1.76 g of a white solid compound 8 was obtained in a yield of 71%.
19064-67-6, 19064-67-6 6-Chloro-3-hydroxypyridazine 252828, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Hu Youhong; Geng Meiyu; Duan Wenwen; Ding Jian; Wan Penghui; Shen Aijun; Lu Dong; Liu Hongchun; Wei Aihuan; Zhang Minmin; Zeng Limin; Cao Jingchen; (57 pag.)CN109280032; (2019); A;,
Pyridazine – Wikipedia
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