With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.
A mixture of 3,4,5-trichloropyridazine (0.446 g, 2.432 mmol), 2- (piperidin-4-yl)-3-(trifluoromethyl)pyridine (0.56 g, 2.432 mmol), and potassium carbonate (0.706 g, 5.11 mmol) in dioxane (8 ml) was heated to reflux for 1 h. The mixture was cooled and 35% hydrazine (4.41 ml, 48.6 mmol) was added. The mixture was heated to reflux for 16 h. The reaction was diluted with ethyl acetate and water. The ethyl acetate layer was washed with water and concentrated to give 4- chloro-3 -hydrazinyl-5-(4-(3 -(trifluoromethyl)pyridin-2-yl)piperidin- 1 -yl)pyridazine as a brown oil. LCMS: Rt = 0.76 min, (M+H)+ = 373.7. The material was used without purification., 14161-11-6
As the paragraph descriping shows that 14161-11-6 is playing an increasingly important role.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
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