187973-60-0, 6-Iodopyridazin-3-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example B.72-Cyclopropyl-6-iodo-3-methyl-imidazo[1,2-b]pyridazine A mixture of 2-bromo-1-cyclopropylpropan-1-one (0.72 g, 2.03 mmol) and 6- iodopyridazin-3-amine (449 mg, 2.03 mmol) in 1,2-dimethoxyethane (10 ml) was refluxed under an argon atmosphere for 20 hrs. After cooling to r.t, the solvent was evaporated. The crude product was taken up in water (1 5m1) and extracted with EtOAc The organic s were dried overMgSO4, filtered and evaporated. The aqueous layer was neutralized by addition of iN NaOH and then extracted extracted with CH2C12. The organic layer was dried over MgSO4, filtered and evaporated. The two organic extracts were combinated and concentrated. The crude product was purified by silica gel chromatography using a heptane/EtOAc gradient as eluent to provide the title compound (30 mg, 5%; not clean) as light brown solid. MS (mle): 300.3 (M+H)., 187973-60-0
The synthetic route of 187973-60-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; WO2015/113980; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem