With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20698-04-8,3,6-Diiodopyridazine,as a common compound, the synthetic route is as follows.
To a solution of compound 2 (1.40 g, 4.22 mmol) in methanol (20 mL) was added CH3ONa (0.34 g, 6.33 mmol), and the mixture was stirred at 80C for 1 h. The reaction was quenched by addition of water (20 mL), then extracted with CH2Cl2 (10 mL x 3). The combined organic layer was dried over sodium sulfate, filtered, concentrated under reduced pressure and purified by silica gel column chromatography to give compound 3 (0.97 g, 97%) as a colored solid, mp 96 – 98C., 20698-04-8
The synthetic route of 20698-04-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Yue, Qiming; Zhao, Yi; Hai, Li; Zhang, Tao; Guo, Li; Wu, Yong; Tetrahedron; vol. 71; 40; (2015); p. 7670 – 7675;,
Pyridazine – Wikipedia
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