Brief introduction of 65202-50-8

65202-50-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65202-50-8,Methyl 6-chloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.

Step 2; Methyl 6-(G-?)-3-r2-(trifluoromethyl)phenoxylpyrrolidin-l-vpipyridazine-3-carboxylate; A mixture of methyl 6-chloropyridazine-3-carboxylate (1.1 g, 6.4 mmol), (35)-3-[2- (trifluoromethyl)phenoxy]pyrrolidine (1.6 g, 6.9 mmol), potassium carbonate (1.8 g, 12.7 mmol) and tetrabutylammonium iodide (47 mg, 0.13 mmol) in dioxane (60 mL) was heated at 90-95 0C bath for 24 h. After cooling, the mixture was filtered through celite, washed with EtOAc and concentrated. The residue was re-dissolved in EtOAc, washed twice with water, dried and concentrated in vacuo, and swished with Et2O:hexane to give the title compound as a brown powder. EPO 1H NMR (500 MHz, acetone-d6): delta 7.88 (d, 1 H), 7.69-7.63 (m, 2 H), 7.43 (d, 1 H), 7.15 (t, 1 H), 6.96 (d, 1 H), 5.53 (s, 1 H), 4.00 (m, 3H), 3.90 (s, 3 H), 3.75 (m, 1 H), 2.54-2.44 (m, 2 H).

65202-50-8 Methyl 6-chloropyridazine-3-carboxylate 12379801, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/9236; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem