With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.933-76-6,4,5-Dichloro-2-methylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.,933-76-6
4,5-dichloro-2-methylpyridazin-3(2H)-one (200 mg, 1.1 17 mmol), 3-aminoazocan-2-one (155 mg, 1.09 mmol), N,N-diisopropylehtylamine (0.289 g, 2.23 mmol) and DMAc (1.3 mL) were charged in a sealable vial. The reaction was heated to 120 C for 2 hours. The reaction mixture was partitioned between EtOAc and NaHC03 (aq., sat.). The crude product was purified by flash chromatography (10% to 100% 1 :10:90 NH4OH:MeOH:DCM in DCM, 24g-silica gel column) to afford to sets of fractions containing regioisomers. The later eluting fractions (most polar isomer) was isolated after evaporation under reduced pressure to afford 3-((5-chloro-l -methyl-6- oxo-l ,6-dihydropyridazin-4-yl)amino)azocan-2-one (0.235 g, 0.84 mmol) in 77% yield. LCMS (ESI+): 285 / 287 (M+H, CI pattern).
The synthetic route of 933-76-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; BURDICK, Daniel, J.; COTE, Alexandre; DUPLESSIS, Martin; NASVESCHUK, Christopher, G.; TAYLOR, Alexander, M.; (117 pag.)WO2016/112298; (2016); A1;,
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