65202-50-8, Methyl 6-chloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,65202-50-8
To a suspension of methyl 6- chloropyridazine-3-carboxylate (1 g, 5.8 mmol) and imidazole (400 mg, 5.8 mmol) in dry DMF (10 mL), was added K2CO3 (950 mg, 6.8 mmol) and the reaction mixture was stirred at 120 C for 3h. The reaction was monitored by LCMS. After complete conversion to methyl 6- (1 H-imidazol-1-yl)pyridazine-3-carboxylate, 2.5 M aq. LiOH (2.8 mL, 6.96 mmol) was added to the reaction mixture and stirred at 60 C for 1 h. The reaction was monitored by LCMS. After completion of the reaction, the reaction mixture was acidified with aq.1 M HCI and the resulting precipitate was filtered and washed with water, to obtain the acid A (720 mg) as an off-white solid which was used in the next step without further purification. LC-MS (ESI+): m/z 191.0 [M+H]+.
As the paragraph descriping shows that 65202-50-8 is playing an increasingly important role.
Reference£º
Patent; THE SCRIPPS RESEARCH INSTITUTE; LAIRSON, Luke, L.; CHIN, Emily, N.; CHATTERJEE, Arnab; KUMAR, Manoj; ALBERO, Ana, Maria, Gamo; PETRASSI, Mike; SCHULTZ, Peter; YU, Chenguang; TAMIYA, Junko; VERNIER, William; GUPTA, Anil; MODUKURI, Ramkumar; (0 pag.)WO2019/165032; (2019); A1;,
Pyridazine – Wikipedia
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