With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20698-04-8,3,6-Diiodopyridazine,as a common compound, the synthetic route is as follows.
0.50 mL (6.6 mmol) isopropanol are added to 289 mg (7.23 mmol) sodium hydride (60%) in 100 mL THF and the mixture is stirred for 30 min at rt. After that time, 2.0 g (6.0 mmol) 3,6-diiodo-pyridazine are added and the mixture is stirred for 14 h at rt and for 14 h at 50C. After that time, the mixture is poured into water and extracted with EtOAc. The organic layer is washed with water (2x) and dried over sodium sulphate. The solvent is removed in vacuo and the residue is purified by column chromatography (silicia gel; heptane: EtOAc gradient 0 to 50%).C7H9IN2O (M= 264.06 g/mol)ESI-MS: 265 [M+H]+ Rt (HPLC): 3.14 min (method P), 20698-04-8
20698-04-8 3,6-Diiodopyridazine 250383, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ROTH, Gerald Juergen; FLECK, Martin; NEUBAUER, Heike; NOSSE, Bernd; WO2012/32014; (2012); A1;,
Pyridazine – Wikipedia
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