With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1632-76-4,3-Methylpyridazine,as a common compound, the synthetic route is as follows.
1632-76-4, General procedure: K2[M'(CN)4].H2O was prepared by mixing the stoichiometric amounts of nickel(II) chloride hexahydrate (1 mmol, 0.238 g) or palladium(II) chloride (1 mmol, 0.177 g) or platinum(II) chloride(1 mmol, 0.266 g) in water (10 mL) solutions with potassiumcyanide (4 mmol, 0.260 g) in water (10 mL) solutions. These solutions were filtered and allowed to evaporate at room temperature in order to crystallize. The K2[M'(CN)4]H2O (1 mmol) complexes(M’ , 0.259 g for Ni(II), 0.306 g for Pd(II), 0.395 g for Pt(II)) were dissolved in water (50 mL). To these solutions, 1 mmol of zinc(II) chloride or 1 mmol of cadmium(II) chloride hemi(pentahydrate)dissolved in water (10 mL) were added with continuous stirring approximately for 4h at 50¡ãC in a temperature-controlled bath.The M[M'(CN)4]H2O compounds obtained were filtered and dried in air. The complexes were prepared by mixing together with the50 mL of water solution of 1 mmol of Zn[Ni(CN)4]H2O = 0.246 g,Zn[Pd(CN)4]H2O = 0.293 g or Zn[Pt(CN)4]H2O = 0.382 g, separately.To M[M'(CN)4]H2O solutions, 3-mpdz (2 mmol, 0.188 g) dissolved in ethanol (10 mL) was added with continuous stirring and after afew minutes ammonia (5 mL, 28percent) was added a few drops to resulting solution with continuous stirring approximately for 5h at 60¡ãCin a temperature-controlled bath and then filtered. The resulting clear solutions were kept for crystallization at room temperature. In the meantime, the ammonia was moved away from the solutions itself. Within about a week bright crystals were obtained. The procedure for the syntheses of cadmium complexes was similar to that used for zinc complexes, except that the Zn[M'(CN)4]H2Owas used instead of Cd[M'(CN)4]H2O [Cd[Ni(CN)4]H2O = 0.246 g,Cd[Pd(CN)4]H2O = 0.340 g or Cd[Pt(CN)4]H2O = 0.429 g]. The C, H,N analyses were carried out for the complexes and were found tofit the proposed formulae well.
The synthetic route of 1632-76-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Goer, Kansu; Kuerkcueo?lu, Guene? Sueheyla; Ye?ilel, Okan Zafer; Bueyuekguengoer, Orhan; Inorganica Chimica Acta; vol. 414; (2014); p. 15 – 20;,
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