With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1120-88-3,4-Methylpyridazine,as a common compound, the synthetic route is as follows.
1120-88-3, 3-(2,6-difluorophenyl)-2-fluorobenzoate (9.0 g, 0.026 mol) was dissolved in dry tetrahydrofuran (5 mL), the reaction flask was placed in a dry ice bath, cooling to -20C .Under nitrogen, was added dropwise LiHMDS (50 mL, 0.050 mol) was stirred for half an hour, the reaction flask moved to 0C ice bath, was slowly added dropwise 4-methyl pyridazine (2.5g, 0.027 mol), dropwise reactions were complete in 2 hours under ice-cooling, warmed to room temperature, saturated ammonium chloride solution (30 mL), (100 mL) and extracted with ethyl acetate, the organic phase was washed with water (30 mL) and saturated sodium chloride solution ( 30 mL), dried over anhydrous sodium sulfate, and the solvent removed by rotary evaporation, chromatographed to give the product (6.5 g, 61% yield) by silica gel column.
1120-88-3 4-Methylpyridazine 136882, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; Tonghua Jida Pharmaceutical Co., Ltd.; Wu, yongqian; (22 pag.)CN103936728; (2016); B;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem