With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35857-89-7,6-Chloropyridazine-3-carbonitrile,as a common compound, the synthetic route is as follows.
Step 2) 6-(4-((5-chloro-2-((2,3-dimethyl-2H-indazol-6-yl)amino)pyrimidin-4-yl)(methyl)amino)-3-ethylpiperidin-1-yl)pyridazine-3-carbonitrile To a solution of 5-chloro-N2-(2,3-dimethyl-2H-indazol-6-yl)-N4-(3-ethylpiperidin-4-yl)-N4-methylpyrimidine-2,4-diamine (134.5 mg, 0.33 mmol) in ethanol (5 mL) were added 6-chloropyridazine-3-carbonitrile (69.1 mg, 0.50 mmol) and triethanamine (0.15 mL, 1.1 mmol). The mixture was stirred at 30 C. overnight, and concentrated in vacuo. The residue was purified by preparative TLC (MeOH/DCM (v/v)=1/15) to afford the target compound as a yellow solid (87.4 mg, yield 52.0%). LC-MS (ESI, pos. ion) m/z: 517.3 [M+H]+. 1H NMR (600 MHz, CDCl3) delta (ppm): 8.05 (s, 1H), 7.99 (s, 1H), 7.48-7.42 (m, 2H), 7.05 (s, 1H), 6.91 (dd, J=8.9, 1.3 Hz, 1H), 6.88 (d, J=9.6 Hz, 1H), 4.83-4.81 (m, 1H), 4.61-4.54 (m, 2H), 4.03 (s, 3H), 3.33 (t, J=12.1 Hz, 1H), 3.04 (s, 3H), 2.84-2.76 (m, 1H), 2.57 (s, 3H), 2.17-2.14 (m, 1H), 1.85-1.77 (m, 2H), 1.63-1.59 (m, 1H), 1.16-1.09 (m, 1H), 0.95 (t, J=7.5 Hz, 3H)., 35857-89-7
The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sunshine Lake Pharma Co., Ltd.; Calitor Sciences, LLC; Xi, Ning; Li, Minxiong; Li, Xiaobo; Dai, Weilong; Hu, Haiyang; Zhang, Tao; Chen, Wuhong; (78 pag.)US2016/229837; (2016); A1;,
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