1120-88-3, 4-Methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred mixture of 4-Methyl-pyridazine (11) (0.500 g, 5.312 mmol) and Benzaldehyde (12) (1.1 g, 10.625 mmol) was added zinc chloride (1.44 g, 10.625 mmol) and the resultant reaction mixture was heated at 150C for 16h. The reaction mixture was quenched with 2M NaOH solution and DCM was added. The layers were partitioned and the aqs part was further extracted with DCM (2 times). The combined organic layers were dried over sodium sulfate and concentrated. Portioned between 2M NaOH and DCM and extracted the aqueous layer with DCM. Combined all organic layers and dried over Sodium sulphate. The crude was purified by column chromatography in 100-200 silica using Hexane/EtOAc (4: 1) as eluent to afford Intermediate 13 (290mg, 29.9%) as brown oil.
1120-88-3, 1120-88-3 4-Methylpyridazine 136882, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; THE BROAD INSTITUTE, INC.; THE GENERAL HOSPITAL CORPORATION; INSTITUTO CARLOS SLIM DE LA SALUD; BURNS, Sean, M.; WAGNER, Bridget, K.; VETERE, Amedeo; (189 pag.)WO2018/175324; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem