7252-84-8, 3-Amino-6-methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7252-84-8
Intermediate 51: 4-{F(3,5-d imethyl-4-isoxazolyi)methyl]oxy}-N-F6-(methyloxy-3-Ivridazinvl]benzenesulfona mideTo a solution of 6-methoxypyridazin-3-amine (125 mg, 1.0 mmol) in pyridine (8 mL) at roomtemperature, was added 4-{[(3,5-d imethyl-4-isoxazolyl)methyl]oxy}benzenesulfonyl chloride (0.302g, 1.0 mmol). The reaction mixture was stirred at 20 C for 18 hours. The solvent was evaporated invacuo and passed through an aminopropyl (NH2) solid phase extraction (SPE) cartridge eluting withmethanol, followed by a sulphonic acid (SCX) SPE cartridge eluting with methanol. The crude wasthen purified by flash silica (Si) chromatography (0-100% ethyl acetate-cyclohexane+0-25%methanol gradient), to provide the title compound (16 mg). LCMS (2 mm, formic) Rt 0.83 mi m/z(ESj 391 (M+H).
The synthetic route of 7252-84-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; BIRAULT, Veronique; CAMPBELL, Amanda, Jennifer; HARRISON, Stephen; LE, Joelle; SHUKLA, Lena; WO2013/160419; (2013); A1;,
Pyridazine – Wikipedia
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