Some tips on 141-30-0

141-30-0 3,6-Dichloropyridazine 67331, apyridazine compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141-30-0,3,6-Dichloropyridazine,as a common compound, the synthetic route is as follows.

To 3,6-dichloropyridazine (4g, 26.8mniol) and sodium iodide (5.4g, 35.9mmol) was added hydriodic acid (20ml) and the mixture was heated to 400C for 18 hours. After cooling to room temperature the material was poured onto ice and stirred in a beaker (500ml). The aqueous acid was basified (pH>12) by addition of sodium hydroxide (cone, 15ml) and water (20ml). Dichloromethane (40ml) was added to the aqueous and collected. The dichloromethane layer was then dried filtered and evaporated to obtain the title compound as a brown solid (6.3g).1H-NMR (CDCl3) delta 7.21 (IH, d, J = 9), 7.82 (IH, d, J= 8)LC/MS m/z [MH+] 241 consistent with molecular formula C4H235Cl127IN2, 141-30-0

141-30-0 3,6-Dichloropyridazine 67331, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2008/116816; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem