135034-10-5, 3-Chloro-6-iodopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
XlV.i .a [3-(6-Chloro-pyridazin-3-yl)-prop-2-vnyl1-carbamic acid tert-butyl ester; 19.2 g (80.0 mmol) 3-Chloro-6-iodo-pyridazine (Tetrahedron 55, 1999, 15067) and 13.7 g (88.0 mmol) prop-2-ynyl-carbamic acid tert-butyl ester are dissolved in 200 ml THF and 2.50 g (4.0 mmol) bis-(triphenylphosphine)palladiumdichloride, 2.80 g (14.8 mmol) copper-(l)- iodide and finally 60 ml diisopropylamine are added at 0C. The mixture is stirred for 2 hours at 0C. After that time ice-water is added and the mixture is extracted with ethylacetate. The organic phase is separated and dried over sodium sulphate. The solvent is evaporated and the residue is purified by silica gel column chromatography with methylene chloride/ethyl acetate (5:1 ) as eluent. The product is dried in vacuo at 50C. Yield: 12.8 g (60% of theory), Rf value: 0.50 (silica gel, methylene chloride/ethyl acetate = 5:1 ) Ci2H12CIN3O2EII Mass spectrum: m/z = 268/270 [M+H]+ M. p. 102-105 C
135034-10-5, 135034-10-5 3-Chloro-6-iodopyridazine 15418839, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2007/48802; (2007); A1;,
Pyridazine – Wikipedia
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