With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1120-95-2,3-Chloropyridazine,as a common compound, the synthetic route is as follows.
General procedure: A flask was charged with 2-formylpyrrole 1 (5.00 g, 52.6 mmol), K2CO3 (8.72 g, 63.1 mmol), 2-fluoropyridine 2 (9.0 mL, 105.2 mmol) and DMF (26 mL).The mixture was heated at 100 C for 20 h and then cooled to rt. The reaction mixturewas diluted with water, extracted with MTBE, and the organic phase was dried (MgSO4), filtered, and concentrated. The crude product was purified by chromatography on SiO2(hexanes/EtOAc, 95:5 to 85:15 v/v) to give the product 3 (5.71 g, 63%) as a tan solid., 1120-95-2
As the paragraph descriping shows that 1120-95-2 is playing an increasingly important role.
Reference£º
Article; Reeves, Jonathan T.; Han, Zhengxu S.; Goyal, Navneet; Lee, Heewon; Busacca, Carl A.; Senanayake, Chris H.; Tetrahedron Letters; vol. 55; 15; (2014); p. 2492 – 2494;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem