With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.289-80-5,Pyridazine,as a common compound, the synthetic route is as follows.
The synthesis of 3 was similar to that of complex 1, but pyromellitic acid (H4pma) was used instead of H3btc. Reaction of AgNO3 (33.4 mg, 0.2 mmol), pyridazine (pdz)(16.0 mg, 0.2 mmol) and 1,3,5-benzene tricarboxylic (H3btc)(44.2 mg, 0.2 mmol) took place in H2O-DMF (N,N-Dimethylformamide)solvents (6 ml, v/v = 1:1) in the presence of ammonia(0.5 mL, 14 M) under ultrasonic treatment (160 W, 40 kHz,30 min) at 40 C. The resultant colourless solution was allowed slowly to evaporate at room temperature in the dark. The yellowcrystals of complex 1 were obtained after several days.The crystals were isolated by filtration and washed by deionized water and ethanol and dried in the air. And clear yellowish crystals of 3 were obtained in 81% yield based on Ag. Elementalanalysis: Anal. Calc. for Ag2C9H5N2O4: C, 25.684; H, 1.197; N,6.656. Found: C, 25.59; H, 1.28; N, 7.06%. Selected IR peaks(cm1): 3410 (m), 3072 (w), 3010 (w), 1576 (s), 1481 (m), 1411(s), 1315 (m), 1264 (m), 1131 (m), 1054 (w), 972 (m), 920 (w),857 (m), 805 (m), 767 (m), 670 (m), 576 (w), 525 (m), 435(m)., 289-80-5
As the paragraph descriping shows that 289-80-5 is playing an increasingly important role.
Reference£º
Article; Wang, Dan-Feng; Zhang, Ting; Dai, Si-Min; Huang, Rong-Bin; Zheng, Lan-Sun; Inorganica Chimica Acta; PA; (2014); p. 193 – 200;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem