5469-70-5, 3-Aminopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Under an atmosphere of nitrogen, a 25 mL dry Schlenk flask was placed with Cu(acac)2 (1.6 mg, 0.01 mmol) and ligand A (2.6 mg, 0.012 mmol). Anhydrous MeOH (1.0 mL) was added, and the mixture was magnetically stirred at 20 C for 15 min. Then a solution of 1-phenylprop-2-yn-1-yl acetate 2a (0.24 mmol), 2-aminopyridine 1a (0.2 mmol) and diisopropylethylamine (0.07 mL, 0.4 mmol) in MeOH (0.5 mL) were added dropwise. The reaction flask was kept at room temperature for 6 h. After 1a was completely consumed as monitored by TLC, H2O (10 mL) was added to quench the reaction. The resulting mixture was then extracted three times with diethyl ether (10 mL*3). The combined organic layer was dried over Na2SO4. After evaporation of the volatile solvent under reduced pressure, the residue was purified by flash chromatography on silica gel to afford pure 3a (39 mg, 0.19 mmol) as a brown oil in a yield of 94%., 5469-70-5
The synthetic route of 5469-70-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Cheng, Cang; Ge, Luo; Lu, Xuehe; Huang, Jianping; Huang, Haocheng; Chen, Jie; Cao, Weiguo; Wu, Xiaoyu; Tetrahedron; vol. 72; 43; (2016); p. 6866 – 6874;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem