With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5788-58-9,4,5-Dibromopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.
5788-58-9, A mixture of 25 g (0.1 mol) of 4,5-dibromo-3 (2H) -pyridazinone, 93 g (0.5 mol) of tributylamine,(HFC-23) at room temperature, and the mixture was stirred at 80 C, and the reaction was carried out. After the reaction was followed by thin layer chromatography, the reaction mixture was cooled with 10 ml of methylene chloride And purified by column chromatography (the stationary phase was silica gel GF254, eluent ethyl acetate / petroleum ether V / V = 1: 1) to give 17.2 g of a white solid product as a white powder,Yield 90%.
As the paragraph descriping shows that 5788-58-9 is playing an increasingly important role.
Reference£º
Patent; Pei, Qing; (6 pag.)CN106083731; (2016); A;,
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