With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35857-89-7,6-Chloropyridazine-3-carbonitrile,as a common compound, the synthetic route is as follows.
5-Chloro–N2- (1,5- dimethyl -1H- pyrazol-3-yl) -N4- (3- ethyl-piperidin-4-yl) pyrimidine-2,4-diamine (0.12g , 0.34mmol) was suspended (10.OmL) at EtOH, to which was added 6-chloro-pyridazin-3-carbonitrile (96mg, 0.69mmol) and triethylamine (0.15mL, 1.10mmol). The reaction system was stirred at 40 overnight, then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (MeOH solution of DCM / 3M NH3 in the (v / v) = 100/1 to 75/1 to 50/1) to give the title compound as a yellow solid (45mg, yield 29% ).
35857-89-7, The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Xi, Ning; Li, Minxiong; Li, Xiaobo; Dai, Weilong; Hu, Haiyang; Zhang, Tao; Chen, Wuhong; (105 pag.)CN105461694; (2016); A;,
Pyridazine – Wikipedia
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