With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.372118-01-9,Methyl 4,6-dichloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.
Compound 4,6-dichloropyridazine-3-carboxylate 1a (199 mg, 0.96 mmol),1- (4-aminophenyl) -4-methylpiperazin-2-one (197 mg, 0.96 mmol),Diisopropylethylamine (1.24 g, 9.60 mmol) and acetonitrile (5 mL) were mixed, heated to 90 C and stirred for 6 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate / methanol = 100/0 to 1/1),The target product 6-chloro-4-((4- (4-methyl-2-oxopiperazin-1-yl) phenyl) amino) pyridazine-3-carboxylic acid methyl ester 103a (97 mg, yellow oily ),Yield: 27%.
372118-01-9, 372118-01-9 Methyl 4,6-dichloropyridazine-3-carboxylate 17848322, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem