5096-73-1, 6-Chloropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5096-73-1, General procedure: 6-Chloropyridazine-3-carboxylic acid (1 equivalent) was dissolved in DCM (10ml). To this solution catalytic amount of DMF and oxalyl choloride (1.1 equivalent) were added and the reaction mixture was stirred at room temperature for 2h. After 2h, reaction mixture cooled at ice bath then, TEA (3 equivalent) and appropriate 2-substituted ethan-1-amine derivative (1.1 equivalent) were added and stirred for additional 1h at room temperature. At the end of this period, reaction mixture was evaporated to dryness then the precipitate boiled with water and petroleum ether respectively. The resulting precipitate was filtered to yield intermediates (1-4), which were used for method A without further purification.
The synthetic route of 5096-73-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Kilic, Burcu; Gulcan, Hayrettin O.; Aksakal, Fatma; Ercetin, Tugba; Oruklu, Nihan; Umit Bagriacik; Dogruer, Deniz S.; Bioorganic Chemistry; vol. 79; (2018); p. 235 – 249;,
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