With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17973-86-3,3,6-Dibromopyridazine,as a common compound, the synthetic route is as follows.
A suspension of 3,6-dibromopyridazine and 4-hydroxypiperidine (1.5 equiv.) in isopropanol (2 M) was heated in microwave at 150 0C. After a period of 20 min., the crude residue was partitioned between ethyl acetate and water. The organic phase was separated, dried over MgSO4, filtered and evaporated under reduced pressure. The title compound was purified by flash chromatography eluting with 50% acetone in dichloromethane, 17973-86-3
The synthetic route of 17973-86-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2008/46226; (2008); A1;,
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