5096-73-1, 6-Chloropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of -chloropyridazine-S-carboxylic acid (60mg, 0 38mmol) in THF (1OmL) was added EDCI (107mg, 0 46mmol), followed HOBt (69mg, 0.46mmol), and the reaction was stirred at r.t. for 15 min. 4-[(^)-l-(N-Hydroxycarbamimidoyl)ethoxy]piperidine-l- carboxylic acid isopropyl ester (Preparation 12, 103mg, 0 38mmol) was added and stirring continued for 4 h, before removing the solvent in vacuo The resulting residue was partitioned between EtOAc and water, then the organic phase was separated, washed with sat NaHCO3 solution, dried (MgSO4) and the solvent removed in vacuo. The residue was dissolved in toluene and heated to reflux for 16 h before concentrating the solvent in vacuo and redissolving the product in EtOAc. The solution was washed with water, then brine, and dried (MgSOzO, before removal of the solvent in vacuo Purification by column chromatography (IH:EtOAc, 1 1) afforded the title compound: RT = 3.87 min, m/z (ES+) = 495.2 [M + H]+, 5096-73-1
As the paragraph descriping shows that 5096-73-1 is playing an increasingly important role.
Reference£º
Patent; PROSIDION LIMITED; BARBA, Oscar; DAVIS, Susan, Helen; FYFE, Matthew, Colin, Thor; JEEVARATNAM, Revathy, Perpetua; SCHOFIELD, Karen, Lesley; STAROSKE, Thomas; STEWART, Alan, John, William; SWAIN, Simon, Andrew; WITHALL, David, Matthew; WO2010/103335; (2010); A1;,
Pyridazine – Wikipedia
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