With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66346-87-0,6-Chloro-5-methylpyridazin-3-amine,as a common compound, the synthetic route is as follows.
The reaction is performed underan argon-atmosphere. 6-Chloro-5-methylpyridazin-3-amine (3.00 g; 20.90 mmol), ie/f-butyl 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 ,2,3,6- tetrahydropyridine-1 -carboxylate (7.1 1 g; 22.98 mmol) and sodium carbonate (2 mol/L, aq. solution; 41 .79 mL; 83.58 mmol) in 1 ,4-dioxane (150 mL) is purged with argon. After 5 minutes Xphos 2nd Gen. (0.49 g; 0.63 mmol) is added and the mixture is stirred over night in a sealed vial at 100C. The reaction mixture is concentrated under reduced pressure. The residue is taken up in water and extracted several times with EtOAc. The combined organic layers are washed with brine, dried over Na2S04, filtered and concentrated under reduced pressure. The residue is purified by silica gel chromatography (DCM/MeOH). (1086) Yield: 5.20 g (86%) ESI-MS: m/z = 291 [M+H]+ Rt(HPLC): 0.79 min (method 10), 66346-87-0
The synthetic route of 66346-87-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HYDRA BIOSCIENCES, INC.; BOUYSSOU, Thierry; GOTTSCHLING, Dirk; HEINE, Niklas; SMITH KEENAN, Lana Louise; LOWE, Michael D.; RAZAVI, Hossein; SARKO, Christopher Ronald; SURPRENANT, Simon; TAKAHASHI, Hidenori; TURNER, Michael Robert; WU, Xinyuan; (182 pag.)WO2019/81637; (2019); A1;,
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